Free practice questions · NCLEX-PN · Infection control

NCLEX-PN infection control practice questions.

Standard and transmission-based precautions, isolation, PPE, hand hygiene and sterile technique. Ten questions from the Lumen Nursing NCLEX-PN bank, written to the LPN and LVN scope. Answer each one and check it; the rationale explains the key and every other option.

1Multiple choice, single answerFundamentals

Four days after admission to an airborne infection isolation room, a 39-year-old client whose sputum smears are positive for acid-fast bacilli paces the room, says, "I can't stand being locked in here. I'm going home today," and begins packing a bag. Which of the following actions should the nurse take?

Call the health care provider for a prescription for an antianxiety medication
Stay with the client and ask what has been the hardest part of being in the room
Tell the client that leaving would break the law and that security will be called
Allow the client to walk in the hallway wearing a surgical mask to relieve the stress
Answer it, then check it.
Answer and rationale
Answer
  • B: Stay with the client and ask what has been the hardest part of being in the room
The key, and why
Airborne isolation for tuberculosis means days to weeks in a single closed room, often far from family and work. Anxiety, boredom, anger, and a wish to leave are common. A client who walks out while still infectious is a risk to the public, and in most places the health department can legally require isolation, but a calm conversation is far more likely to keep the client in the room than a threat. The nurse stays, uses a calm tone, and asks an open question about what has been hardest. That lets the client vent and tells the nurse what is driving the distress, whether it is boredom, worry about a job or children, cost, or fear. The nurse can then work with the client on what can change, such as a phone, a laptop, visits from family members already exposed, or a daily schedule, and report the client's distress to the registered nurse (RN) so a social work referral can follow.
Each distractor
Option A reaches for medication before the nurse has explored the cause. Medication may help later, but it does not address what is driving the client to leave. Option C opens with a threat. Confrontation raises anger and makes the client more likely to leave, and the legal route is a last resort handled by the provider and health department. Option D takes an infectious client into the hallway. A surgical mask is used for necessary transport, not for walks around the unit.
The teaching point
ISOLATION distress = STAY, LISTEN, ask OPEN questions, then problem-solve. Infectious TB client stays in the AIRBORNE room. Legal action is a LAST resort.
2Multiple choice, single answerAdult Health

At a community HIV clinic, a client who was newly diagnosed with HIV infection started antiretroviral therapy (ART) 2 weeks ago. At a follow-up visit, the nurse collects data on how the client is coping with the diagnosis and the daily medication. Which statement by the client requires follow-up?

"I still cry some nights, but I set a phone alarm for my evening pills."
"I told my sister about the diagnosis, and she checks in with me most days."
"I'd rather not see my friends right now, and the pills can wait until I feel better."
"Some days I feel angry about it, so I've started going to a support group."
Answer it, then check it.
Answer and rationale
Answer
  • C: "I'd rather not see my friends right now, and the pills can wait until I feel better."
The key, and why
A new HIV diagnosis brings a period of shock, anger and grief, and those feelings are expected. What the nurse watches for is the move from distress into hopelessness and withdrawal, because that signals ineffective coping and possible depression. This client describes two warning signs in one statement: withdrawing from friends and putting off the medication until some later point. The missed doses add a physical danger, because antiretroviral drugs only work when blood levels stay steady, and repeated gaps let the virus multiply and develop resistance. The nurse explores the statement further, asks directly about thoughts of self-harm, and reports it to the registered nurse (RN) and health care provider so that mental health support and adherence help can be arranged.
Each distractor
Option A shows sadness alongside a practical adherence strategy, which is effective coping. Option B shows the client has chosen a support person, which protects against isolation. Option D describes anger, a normal response to a new diagnosis, being channeled into a support group, which is healthy coping.
The teaching point
New diagnosis: ANGER and GRIEF are expected. HOPELESSNESS and WITHDRAWAL are not. WITHDRAWING from others + putting off treatment = INEFFECTIVE COPING. Follow up and report. Missed ART doses = RESISTANCE.
3Matrix gridCritical Care

The nurse on a medical unit is reviewing the transmission precautions for five clients with varicella-zoster virus infections. For each client, click to specify if the client requires standard precautions or airborne and contact precautions.

Finding
Standard precautions
Airborne and contact precautions
Shingles across several dermatomes on both sides of the trunk after a kidney transplant
Shingles in one dermatome on the left side of the chest of a healthy 70-year-old
Shingles in one dermatome of the face in a client taking high-dose corticosteroids
Shingles on the back of a healthy adult with every lesion dried and crusted
New chickenpox vesicles on the trunk and face of a 30-year-old
Answer it, then check it.
Answer and rationale
Answer
  • Shingles across several dermatomes on both sides of the trunk after a kidney transplant: Airborne and contact precautions
  • Shingles in one dermatome on the left side of the chest of a healthy 70-year-old: Standard precautions
  • Shingles in one dermatome of the face in a client taking high-dose corticosteroids: Airborne and contact precautions
  • Shingles on the back of a healthy adult with every lesion dried and crusted: Standard precautions
  • New chickenpox vesicles on the trunk and face of a 30-year-old: Airborne and contact precautions
The key, and why
Chickenpox and shingles are caused by the same virus, varicella-zoster. Chickenpox spreads through the air and through contact with fluid from the blisters. Shingles is the same virus reactivating along a nerve, and how far it can spread depends on how widely the rash is spread and on the client's immune system. Chickenpox, and shingles that has spread across several dermatomes, called disseminated zoster, both release virus into the air. They need an airborne infection isolation room, an N95 respirator and gown and gloves until every lesion is dry and crusted. A client whose immune system is suppressed, such as a client taking high-dose corticosteroids, is placed on airborne and contact precautions even with a rash in one dermatome, until the health care provider has ruled out spread, because these clients can have virus in the blood and lungs before new lesions appear.
Each distractor
Shingles in one dermatome in a healthy client does not need airborne precautions. Standard precautions with the lesions completely covered by a dressing are enough, because the virus spreads only through direct contact with blister fluid. Disseminated shingles after a transplant does not fit standard precautions. The virus spreads through the air as well as by contact. Localized shingles on high-dose corticosteroids does not fit standard precautions, because dissemination has not yet been ruled out in a client with suppressed immunity. Chickenpox does not fit standard precautions. It is one of the most contagious airborne infections. Crusted lesions do not need airborne and contact precautions. Once every lesion is dry and crusted, the client is no longer infectious.
The teaching point
LOCALIZED shingles + HEALTHY immune system = STANDARD precautions, lesions COVERED. DISSEMINATED shingles, CHICKENPOX, or ANY shingles in an IMMUNOSUPPRESSED client = AIRBORNE + CONTACT. Continue until ALL lesions are DRY and CRUSTED. Staff without varicella immunity stay out of the room.
4Multiple choice, single answerPharmacology

A client with a systemic fungal infection is receiving conventional amphotericin B by intravenous infusion once daily. Before the next dose, the nurse reviews the morning laboratory results. Which result is most important for the nurse to report to the registered nurse (RN)?

Serum sodium of 133 mEq/L
Fasting blood glucose of 146 mg/dL
Serum potassium of 3.0 mEq/L
Hemoglobin of 11.6 g/dL, down from 12.4 g/dL last week
Answer it, then check it.
Answer and rationale
Answer
  • C: Serum potassium of 3.0 mEq/L
The key, and why
Amphotericin B is a powerful antifungal with serious adverse effects. It damages the kidney tubules, which waste potassium and magnesium, so hypokalemia and hypomagnesemia are common, and the serum creatinine can rise. A potassium of 3.0 mEq/L, below the normal range of 3.5 to 5.0 mEq/L, can cause muscle weakness and dangerous dysrhythmias, so it is reported before the next dose so replacement can be prescribed. Infusion reactions with fever, chills and rigors are also common, so the client is often premedicated with acetaminophen and diphenhydramine as prescribed, and the infusion runs slowly over several hours. The nurse monitors intake and output, the kidney function tests, the electrolytes and the client's temperature. Premedicate as prescribed, infuse slowly, monitor creatinine and electrolytes.
Each distractor
Option A is mildly low and is followed, but a sodium of 133 mEq/L does not threaten the heart the way the potassium does. Option B is raised and is reported in the usual way, but it is not related to amphotericin and is not dangerous before the next dose. Option D shows the slow anemia amphotericin can cause over weeks. It is followed, but a gradual fall to 11.6 g/dL is less urgent than a potassium that can cause dysrhythmias.
The teaching point
AMPHOTERICIN B = kidney damage, LOW potassium and magnesium, fever and chills, slow anemia. Several abnormal labs = report the one that can affect the HEART first (potassium).
5Select all that applyLeadership and Management

The registered nurse (RN) has completed the discharge teaching for a 54-year-old client on a medical unit who is going home today after treatment for a kidney infection. Which of the following actions may the nurse take during the client's discharge?

Remove the client's peripheral IV catheter and check that the catheter tip is intact
Reinforce the RN's teaching about taking every dose of the oral antibiotic until the course is finished
Explain the purpose and side effects of a new medication that the RN did not include in the teaching
Check the client's identification band against the name on the discharge papers before handing them over
Give the client the rest of the unit's supply of the oral antibiotic to take at home
Answer it, then check it.
Answer and rationale
Answer
  • A: Remove the client's peripheral IV catheter and check that the catheter tip is intact
  • B: Reinforce the RN's teaching about taking every dose of the oral antibiotic until the course is finished
  • D: Check the client's identification band against the name on the discharge papers before handing them over
The key, and why
The nurse takes a full part in discharge, within scope. Removing a peripheral IV catheter is an LPN/VN skill, and checking that the tip is intact makes sure no piece of the catheter is left in the vein. Reinforcing teaching the RN has already given, such as finishing the whole antibiotic course so the infection does not return in a resistant form, is reinforcement, not initial teaching. Checking identity before handing over discharge papers prevents one client from going home with another client's medication list and instructions.
Each distractor
Option C is the right idea for the client. It is just not an LPN/VN task. Initial teaching about a new medication belongs to the RN, so the nurse tells the RN that the teaching was missed. Option E hands out the unit's medication supply. Dispensing medications to take home belongs to the pharmacy through a prescription.
The teaching point
Discharge, the NURSE = REMOVE the peripheral IV (tip intact), REINFORCE teaching, CHECK identity on the papers. INITIAL teaching about a NEW medication = the RN. Take-home medications = the PHARMACY.
6Multiple choice, single answerPharmacology

A client on a medical unit is prescribed gentamicin. Which of the following infections would the nurse expect this medication to have been prescribed for?

Otitis media with ear pain and a bulging red tympanic membrane
Viral pharyngitis with a sore throat, a dry cough and a low grade fever
An uncomplicated bladder infection with burning on passing urine and frequency
A wound infection covering most of the body after third degree burns
Answer it, then check it.
Answer and rationale
Answer
  • D: A wound infection covering most of the body after third degree burns
The key, and why
Gentamicin is a strong antibiotic given intravenously for serious bacterial infections. It can harm the kidneys and hearing, so levels and kidney function are monitored. Aminoglycosides are the last thing you reach for, not the first. They are reserved for serious, resistant, life-threatening gram-negative infections, because they work when nothing else does and because they are genuinely toxic to the ears and to the kidneys. A large burn colonized with resistant organisms is exactly that kind of infection. The pattern is that an aminoglycoside is held back for a severe infection. Alongside big burns sit septic peritonitis, fulminating pyelonephritis and septic shock: infections that are killing the client or about to. Streptomycin and amikacin are also used in resistant tuberculosis, which is the one place the class steps outside the gram-negative rule, because the tuberculosis organism is neither gram negative nor gram positive. Everything ordinary is treated with something else. Otitis media, sinusitis, strep throat, an uncomplicated bladder infection and anything viral are not severe infections, and putting a client's hearing and kidneys at risk for one of them is not a trade anybody would make.
Each distractor
Option A. Otitis media is treated with an ordinary oral antibiotic. Option B. Viral pharyngitis is not treated with an antibiotic at all. Option C. An uncomplicated bladder infection has several safe oral options and none of them risks the eighth cranial nerve.
The teaching point
An AMINOGLYCOSIDE is for a SEVERE infection. Reserved for serious, resistant, life-threatening infection, usually GRAM NEGATIVE. Septic peritonitis, fulminating pyelonephritis, septic shock, big burns, and resistant TB. NOT for otitis media, sinusitis, strep throat, simple cystitis, or anything viral.
7Multiple choice, single answerMental Health

Two weeks after starting venlafaxine, a 46-year-old client with major depression has more energy, is attending all groups and asks the nurse to have the suicide precautions stopped. Which action should the nurse take first?

Ask the client directly about current thoughts of suicide and any plan
Ask the health care provider to stop precautions because the client's mood is improving
Lower the observation level to checks every 30 minutes as a short trial
Tell the client that precautions continue until the day of discharge
Answer it, then check it.
Answer and rationale
Answer
  • A: Ask the client directly about current thoughts of suicide and any plan
The key, and why
Depression is a treatable condition that causes persistent low mood or loss of interest, hopelessness and changes in sleep, appetite or thinking. Suicide risk can rise during the first weeks of antidepressant treatment, because energy and motivation often return before the low mood and hopelessness lift. A client who once lacked the energy to act on suicidal thoughts may now have it. Before any change in observation, the nurse collects current data by asking directly about suicidal thoughts, intent and plan. The nurse reports the answers to the registered nurse (RN), and the health care provider decides whether the precautions can safely change.
Each distractor
Option B treats more energy as proof of lower risk and asks for a change without current data on suicidal thinking. Option C changes the level of observation on the nurse's own judgment, which is outside the nurse's role, and skips asking about current risk. Option D gives a rule that is not true. Observation levels are adjusted to the client's current risk, not to a set date.
The teaching point
RISK RISES as ENERGY RETURNS early in ANTIDEPRESSANT treatment (first 1 to 4 weeks). ASK DIRECTLY about suicide before ANY change in observation level.
8Select all that applyFundamentals

In a long-term care facility, a nursing student is setting up a sterile field to pack a deep pressure injury while the nurse observes. Which of the following actions by the student require follow-up?

Places a package of sterile gauze about 1/2 inch (1 cm) from the edge of the drape
Turns away from the sterile field to reach the supply cart
Pours sterile saline into the basin from about 5 inches (13 cm) above it
Keeps working after saline spills and soaks through the drape to the table
Discards a pair of forceps that may have brushed the bed rail
Answer it, then check it.
Answer and rationale
Answer
  • A: Places a package of sterile gauze about 1/2 inch (1 cm) from the edge of the drape
  • B: Turns away from the sterile field to reach the supply cart
  • D: Keeps working after saline spills and soaks through the drape to the table
The key, and why
A pressure injury is localized damage to the skin and underlying tissue, usually over a bony prominence, caused by prolonged pressure or pressure plus shear. The outer 1 inch (2.5 cm) of a sterile drape is considered contaminated, so sterile items must be placed inside that border. A sterile field that leaves the nurse's view can no longer be trusted to be sterile, so the nurse never turns away from it. A drape soaked through to a nonsterile surface lets organisms wick up into the field by strike-through, so the field is contaminated and must be set up again.
Each distractor
Option C is correct. Sterile solution is poured from 4 to 6 inches (10 to 15 cm) above the container so the bottle does not touch it and the liquid does not splash. Option E is correct. When there is any doubt about whether an item is sterile, it is treated as contaminated and replaced.
The teaching point
Sterile field rules = 1-INCH border is CONTAMINATED, never turn your BACK, WET field = CONTAMINATED, pour from 4 to 6 INCHES. WHEN IN DOUBT, THROW IT OUT.
9Multiple choice, single answerFundamentals

A 70-year-old client in a skilled nursing facility has an indwelling urinary catheter 5 days after repair of a hip fracture. Which action by the nurse is most effective in reducing the risk of a catheter-associated urinary tract infection (CAUTI)?

Keep the drainage bag below bladder level and off the floor
Irrigate the catheter with 30 mL of sterile saline every 8 hours
Cleanse the urinary meatus with povidone-iodine every shift
Replace the catheter and the drainage system every 72 hours
Answer it, then check it.
Answer and rationale
Answer
  • A: Keep the drainage bag below bladder level and off the floor
The key, and why
A catheter-associated urinary tract infection is an infection of the urinary system caused or encouraged by an indwelling catheter. In older adults it may appear as sudden confusion with few urinary symptoms, and it can progress to more serious infection if untreated. The urinary tract is the portal of entry, and organisms reach the bladder along the catheter or up the drainage system. Keeping the bag below the bladder stops urine from flowing back, and keeping it off the floor stops the bag and spout from picking up organisms. The CDC also recommends a closed drainage system, daily meatal hygiene with soap and water, and removal of the catheter as soon as it is no longer needed.
Each distractor
Option B opens the closed system each time and adds no protection. Routine irrigation is not recommended unless an obstruction is expected. Option C is an outdated practice. Antiseptic cleaning of the meatus does not lower the infection rate; routine hygiene with soap and water is used. Option D adds risk. The catheter and bag are not changed on a fixed schedule; they are changed for blockage, leaks or a break in the closed system.
The teaching point
CAUTI prevention = bag BELOW the bladder, OFF the floor, CLOSED system, soap and water to the meatus, REMOVE the catheter early. NO routine irrigation and NO scheduled catheter changes.
10Select all that applyFundamentals

The nurse is orienting a newly hired licensed practical nurse (LPN) on a surgical unit and watches the newly hired nurse put on sterile gloves before a sterile dressing change. Which of the following actions by the newly hired nurse indicate correct technique?

Opens the glove package on a clean, dry surface that is above waist level
Picks up the first glove by grasping the inside of its folded cuff with the other hand
Performs hand hygiene before opening the outer wrapper of the glove package
Smooths the fingers of the first glove with the bare hand before picking up the second glove
Slides the gloved fingers under the cuff of the second glove to pick it up
Answer it, then check it.
Answer and rationale
Answer
  • A: Opens the glove package on a clean, dry surface that is above waist level
  • B: Picks up the first glove by grasping the inside of its folded cuff with the other hand
  • C: Performs hand hygiene before opening the outer wrapper of the glove package
  • E: Slides the gloved fingers under the cuff of the second glove to pick it up
The key, and why
Sterile gloving keeps the outside of each glove sterile by letting skin touch only the inside of the glove. Hand hygiene comes first, because gloves can have tiny defects and the hands are contaminated again when the gloves come off. The package is opened on a clean, dry surface above the waist, because anything below the waist is out of sight and is considered contaminated, and a wet surface wicks organisms into the wrapper. The first glove is lifted by its folded cuff, which is the part that will lie against the skin, so the bare hand touches only the inside. The second glove is lifted by sliding the gloved fingers under its cuff, so sterile touches sterile. Once both gloves are on, the hands stay above the waist and in front of the body. Watching a new staff member perform a skill and confirming it is done safely is part of verifying that staff can carry out the tasks they are given.
Each distractor
Option D contaminates the first glove. Once a sterile glove is on, it is adjusted only with the other sterile glove, after both are on.
The teaching point
HAND HYGIENE before opening the package. BARE hand touches only the INSIDE of the cuff. GLOVED hand touches only the OUTSIDE of the other glove. Hands ABOVE the waist and IN SIGHT. Adjust fingers only after BOTH gloves are on.

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